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UK funding (1 104 969 £) : Évaluation de l’impact de la propagation des dépolarisations, après un AVC, dans le cerveau éveillé à l’aide de la nanotechnologie activée par le graphène. Ukri01/04/2024 UK Research and Innovation, Royaume Uni
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Évaluation de l’impact de la propagation des dépolarisations, après un AVC, dans le cerveau éveillé à l’aide de la nanotechnologie activée par le graphène.
| Abstract | Stroke is a frequent cause of death and disability in adults worldwide. Ischaemic stroke is the result of a blockage in a cerebral blood vessel that supplies blood to a region of the brain, inducing a severe reduction in cerebral blood flow. Haemorrhagic stroke, or brain bleed, is the result of a cerebral vessel rupturing. This decrease in blood flow, which is needed to provide energy (oxygen and glucose) to the brain, results in the death of brain cells and loss of neurological function. The main damage to the brain happens very quickly, in the first few hours from when the stroke happened but can continue for days or even weeks. The region of the brain which has the lowest blood supply, and where brain cells die the quickest, is called the 'core' region. In contrast brain regions surrounding the core, that have reduced blood flow but with partially functioning brain cells, is called the 'penumbra'. The brain cells in the penumbra may, over time, die which expands the core region and contributes to greater damage to the brain. The penumbra region is the area of the brain that can be saved and is the main target for most stroke therapies. Waves of pathological brain signals called spreading depolarisations (SDs) are known to be major contributors to core expansion, and hence worsen stroke outcome. SDs spontaneously occur in the penumbra region, post stroke, and propagate throughout brain grey matter. As SDs propagate through the brain they depolarise brain cells and result in almost complete ion homeostasis failure. SDs also induce additional reduction of cerebral blood flow in the penumbra region, a region that is already experiencing a reduction in blood flow. Seizures can also occur post-stroke and their frequency is likely underreported due to the fact that many remain focal with little or no behavioural manifestation. A key problem when conducting research to design therapeutic strategies to suppress SDs is the lack of pre-clinical electrophysiological technology capable of detecting infraslow brain signals (below 0.1 Hz), where SDs are recorded, at high spatiotemporal resolution. The Wykes lab has successfully collaborated with the material scientists who designed and fabricate arrays of graphene-based neurophysiological probes capable of recording SDs across large areas of brain, demonstrating their usefulness for studying pathological brain signals in intact brain. We now aim to bring this cutting-edge technology to pre-clinical stroke research to gain a better understanding of the mechanisms of SD initiation and their involvement in worsening stroke severity, in the awake brain. Furthermore, we aim to design a therapeutic strategy that suppresses SDs and reduces stroke core expansion. This work will be a crucial first step in the maturity of this technology towards future clinical translation where we anticipate that it will greatly facilitate management of patients in the neuro-intensive care units. |
| Category | Research Grant |
| Reference | MR/Y014545/1 |
| Status | Active |
| Funded period start | 01/04/2024 |
| Funded period end | 31/03/2027 |
| Funded value | £1 104 969,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FY014545%2F1 |
Participating Organisations
| University of Manchester |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : The University of Manchester, Manchester, Royaume Uni.
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