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UK funding (715 054 £) : Une intuition : comment les infections bactériennes gastro-intestinales peuvent-elles modifier l’immunité de l’appareil reproducteur féminin et le contrôle des infections … Ukri07/08/2023 UK Research and Innovation, Royaume Uni
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Une intuition : comment les infections bactériennes gastro-intestinales peuvent-elles modifier l’immunité de l’appareil reproducteur féminin et le contrôle des infections sexuellement transmissibles ?
| Abstract | Sexually transmitted infections (STIs) are highly prevalent amongst women in low- and middle-income countries, where they have a devastating impact on women's health and places financial strain on health care systems. Importantly, other infections are also common in these regions, making co-infections likely to occur. Previous studies have shown that gastrointestinal (GI) infections can change immunity and control of unrelated infections at other biological compartments. Bacterial infections of the GI system are common in regions with high rates of STIs, and can cause systemic inflammation. However, little is known about how GI bacterial infections affect immunity in the female reproductive tract (FRT) and susceptibility to infections. We have previously used mouse infection models to that helminth infections can indirectly change FRT immunity and this had a detrimental effect on STI disease. In this study, I will investigate the effects of a remote GI bacterial infection on FRT immunity, how this affects control of common STIs, as well as the effects on fertility. The proposed research will build an important foundation for future human studies. A better understanding of the indirect influences on FRT health, will significantly contribute to STI prevention and treatment in the future. |
| Category | Research Grant |
| Reference | MR/X031993/1 |
| Status | Active |
| Funded period start | 07/08/2023 |
| Funded period end | 06/08/2028 |
| Funded value | £715 054,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FX031993%2F1 |
Participating Organisations
| University of Cape Town | |
| UNIVERSITY OF BIRMINGHAM | |
| University of California Davis |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Cape Town Retirement Fund Retirement Fund, Cape Town, Afrique du Sud.
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