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Financement de l’UE (8 046 250 €) : Optimisation pharmacobolomique personnalisée du traitement de l’hypertension Hor 16/12/2022 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Optimisation pharmacobolomique personnalisée du traitement de l’hypertension
Hypertension, or high blood pressure (BP), is a serious medical condition, and the single biggest contributor to circulatory diseases which continue to dominate as the leading cause of death and morbidity across the EU. It accounts for almost 10 percent of all healthcare-related costs. Systolic hypertension leads to a broad variety of diseases with an immense impact on both patients and healthcare systems. HYPERMARKER will unleash the potential of pharmacometabolomics to provide a ‘smart’ prescription of antihypertensive therapy. Well-phenotyped cohorts from eleven European countries will provide metabolomic profiles and blood samples for pharmacometabolomic assessments to identify predictors of treatment response in hypertension using advanced AI and deep learning methods. Prediction models for individual treatment responses to antihypertensive medication will be clinically validated and refined through an innovative RCT across 4 sites in Europe. The result is a clinical decision support tool that will give clinicians the ability to make an informed selection of whether the patient they are treating will best respond to the use of angiotensin inhibition, calcium antagonists, beta-blockers, or a range of other existing drugs with evidence-based for BP control. To ensure sustainability, the project will also develop a framework for the uptake of this tool in routine care for patients with hypertension across Europe and beyond. HYPERMARKER will be implemented by a group of world-class scientists and clinicians from a diversity of disciplines who have collaborated multiple times and have a track record of leading key national and EU-funded initiatives to deliver high-impact results.
| London School of Economics and Political Science | ? |
| Collaborate Project Management GmbH | 250 000 € |
| Euretos B.V. | 38 000 € |
| European Heart Network Aisbl | 156 250 € |
| Fundacion para La Investigacion del Hospital Clinico de La Comunitat Valenciana, Fundacion Incliva | 325 000 € |
| Roche Diagnostics Nederland B.V. | 18 750,00 € |
| Stichting Amsterdam UMC | 97 500 € |
| Universitaetsklinikum Hamburg-Eppendorf | 915 000 € |
| Universitair Medisch Centrum Utrecht | 2 733 750 € |
| Universiteit Leiden | 2 750 500 € |
| Universiteit Utrecht | 477 500 € |
| Viduet Health B.V. | 284 000 € |
https://cordis.europa.eu/project/id/101095480
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : London School of Economics and Political Science, Londres, Royaume Uni.