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Financement de l’UE (5 387 557 €) : A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis Hor01/05/2022 Programme de recherche et d'innovation de l'UE « Horizon »
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Texte
A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis
According to the WHO Osteoarthritis (OA) is one major course of years lived with disability in the elderly and considered a high burden disease, which makes it a research priority in Europe. There is no cure for OA and SoA treatments need to be reconsidered. Current pharmacological interventions consist of analgesic, anti-inflammatory drugs as well as intraarticular steroids and hyaluronic acid (IA-HA) with moderate efficacy and associated long-term side effects. New medications are thus needed both to alleviate pain and slow down disease progression. Taking advantage of the explosion of RNA technologies in the last years, SINPAIN aims to develop a pipeline of siRNA-based therapy built on the combination of current technologies (dyanmic IA-HA and nanocarriers) that will be designed step-by-step in order to reach a successful management of inflammation and innervation therapy for the treatment of early (grade 0-1) and later stages (grade 3-4) of knee osteoarthritis (OA). To do so, a nanoformulation composed of functional IA-HA that can be loaded with vectors, for the delivery of siRNA targeting IL1? and NGF, and nanocarriers will be developed. In parallel, large effort will focus on understanding the pathological mechanisms of OA. To validate efficacy in relevant potency assays, 3D coculture models will be developed with human cells and tested in unique bioreactors mimicking joint environment and biomechanics. With the identified cell targets, IA-HA will be modified with immunomodulator peptide which will activate the adaptive immune response, responsible for OA regeneration. The 4 pipeline products of SINPAIN will be validated in vivo in a relevant OA model with SoA techniques that will demonstrate the reduced inflammation and pain, as well as the cartilage regeneration for the last product. Taking advantage of all the data obtained during the project, a decision-making tool based on machine learning will be validated to offer patients a personalized therapy.
| The University of Liverpool | ? |
| Asociacion Instituto de Investigacion Sanitaria Biogipuzkoa | 0,00 € |
| Asphalion SL | 204 375 € |
| Eurice European Research AND Project Office GmbH | 460 125 € |
| Fundacion Cidetec | 1 286 250 € |
| Haskolinn I Reykjavik EHF | 462 500 € |
| I3S - Instituto de Investigacao e Inovacao em Saude da Universidade do Porto | 515 515 € |
| Institut National de la Sante et de la Recherche Medicale | 309 146 € |
| OZ Biosciences SAS | 509 605 € |
| THE Regents OF THE University OF California | 525 928 € |
| Universita Degli Studi Del Piemonte Orientale Amedeo Avogadro | 399 363 € |
| Universitat DES Saarlandes | 714 750 € |
https://cordis.europa.eu/project/id/101057778
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : The University of Liverpool, Liverpool, Royaume Uni.