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UK funding (371 618 £) : La régulation d’ADAM17 médiée par iRHOM dans la maladie cutanée et la réparation Ukri27/05/2014 UK Research and Innovation, Royaume Uni
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La régulation d’ADAM17 médiée par iRHOM dans la maladie cutanée et la réparation
| Abstract | Repair of the skin after wounding or chronic illness is a major clinical burden with age and infection being a particular problem. In this study, we have identified, from looking at families with inherited skin disease,two genes called iRHOM2 and ADAM17 generating proteins that interact with each other in skin. This was surprising as the two inherited skin conditions are quite distinct in their clinical presentation. The iRHOM2/ADAM17 interaction appears to play a very important role in the way the keratinocytes (the major cell of the top layer of skin called the epidermis) move and prevent infection after wounding. The increase in ADAM17 by iRHOM2 causes the keratinocytes to release growth factors and anti-inflammatory molecules that make the cells move quicker and prevent bacterial infection. Also it alters the way cells adhere to each other by modifying the cell adhesion machinery (in the desmosome) so they can also move and migrate over the wound much quicker. Thus we believe activation of this pathway may be an attractive target for improved chronic and acute cutaneous wound repair. |
| Category | Research Grant |
| Reference | MR/L010402/1 |
| Status | Closed |
| Funded period start | 27/05/2014 |
| Funded period end | 26/05/2017 |
| Funded value | £371 618,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FL010402%2F1 |
Participating Organisations
| Queen Mary University of London |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Queen Mary University of London, Londres, Royaume Uni.
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