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Financement britannique (133 246 £) : De nouvelles chimiothèques pour libérer le potentiel de la découverte de médicaments à base d’enzymes déubiquitylases Ukri 01/01/2017 Recherche et innovation du Royaume-Uni, Royaume Uni
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De nouvelles chimiothèques pour libérer le potentiel de la découverte de médicaments à base d’enzymes déubiquitylases
| Abstract | Despite advancements in the pharmaceutical industry there remains a significant need for new therapies to address unmet clinical needs. The ubiquitin system defines a cascade of proteins that control regulated protein turnover amongst other functions. Its key role in the regulation of probably the majority if not all cellular proteins and processes means that it presents a deep array of potential drug targets - currently largely untapped by the pharma industry - addressing multiple therapeutic areas including many currently proving challenging such as dementia, cancer and metabolic diseases. Ubiquigent is a world leading provider of biological assay services in this newly emerging ubiquitin system drug discovery space. The main rate limiting factor in ubiquitin system targeted drug discovery is the availability of small molecule chemistry that may provide the starting points for developing drugs against this family of targets. With the help of this grant Ubiquigent will develop first in class ubiquitin system (focussing on the deubiquitylase enzyme sub family) targeted small molecule libraries to unlock ubiquitin system drug discovery across the pharmaceutical industry to enable the development of critical future medicines. |
| Category | Feasibility Studies |
| Reference | 132671 |
| Status | Closed |
| Funded period start | 01/01/2017 |
| Funded period end | 31/12/2017 |
| Funded value | £133 246,00 |
| Source | https://gtr.ukri.org/projects?ref=132671 |
Participating Organisations
| UBIQUIGENT LTD |
£133 246,00 |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Ubiquigent Ltd., Dundee, Royaume Uni.
