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Financement britannique (287 394 £) : Contrôle des rétrotransposons par la chromatine Ukri 01/10/2007 Recherche et innovation du Royaume-Uni, Royaume Uni
Vue d’ensemble
Texte
Contrôle des rétrotransposons par la chromatine
| Abstract | Retrotransposons are mobile genetic elements which are found in the genomes of all eukaryotic organisms including humans. They are structurally and functionally related to retroviruses such as HIV and have the potential to be very harmful to the host organism because they may disrupt genes, alter their expression and can also drive genomic rearrangements. Indeed, occasionally retrotransposons can cause genetic disease and so all organisms must carefully control the expression of such elements. Therefore, the aims of this work are firstly, to study the mechanisms that control the expression of retrotransposons and secondly, to determine the outcomes when these controls are impaired. Retrotransposons that are related to those present in humans are also found in simple organisms such as yeast. Therefore, this study will use the fission yeast to study the control of retrotransposons as this unicellular organism is much easier to study and manipulate than complex multicellular organisms such as a humans. |
| Category | Research Grant |
| Reference | BB/E014445/1 |
| Status | Closed |
| Funded period start | 01/10/2007 |
| Funded period end | 30/09/2010 |
| Funded value | £287 394,00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FE014445%2F1 |
Participating Organisations
| Newcastle University |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Newcastle University, Newcastle Upon Tyne, Royaume Uni.