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Financement britannique (320 502 £) : Dissection du mécanisme par lequel les glycosyltransférases catalysent le transfert de mannosyle Ukri 15/02/2007 Recherche et innovation du Royaume-Uni, Royaume Uni
Vue d’ensemble
Texte
Dissection du mécanisme par lequel les glycosyltransférases catalysent le transfert de mannosyle
| Abstract | The linking of sugars to a variety of different proteins has an important influence on the function of cells. The biological catalysts or enzymes that speed up the reactions in which sugars are linked to other molecules are known as glycosyltransferases. Although these enzymes and are industrially and biologically important, they have not been extensively studied because they are difficult to produce in large amounts. In this project we will take advantage of our ability to produce significant quantities of glycosyltransferases that catalyse the transfer of the sugar mannose onto other molecules. The three dimensional structure of these enzymes will be determined and the information will be used to synthesise inhibitors of these biological catalysts and to use molecular engineering techniques to manipulate their biological properties. |
| Category | Research Grant |
| Reference | BB/E000568/1 |
| Status | Closed |
| Funded period start | 15/02/2007 |
| Funded period end | 14/02/2010 |
| Funded value | £320 502,00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FE000568%2F1 |
Participating Organisations
| Newcastle University | |
| EPSRC |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Newcastle University, Newcastle Upon Tyne, Royaume Uni.
