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Financement britannique (1 281 714 £) : Fonctions du norovirus VP1 : une protéine de capside à multiples facettes Ukri 01/01/2019 Recherche et innovation du Royaume-Uni, Royaume Uni
Vue d’ensemble
Texte
Fonctions du norovirus VP1 : une protéine de capside à multiples facettes
| Abstract | Human noroviruses, commonly known as "winter vomiting disease" are a major cause of gastroenteritis worldwide for which there is no treatment or preventative strategies available. Outbreaks of norovirus often occur in partly enclosed communities, most notably hospital wards and care homes where closes and restrictions apply a drain on healthcare services. In the UK alone every year, norovirus outbreaks result in the loss of over 15,000 bed days and a financial burden of over £100 million. Norovirus infection is estimated to result in the loss of over 200,000 lives each year, primarily in the most vulnerable populations such as found in lower and middle income countries (LIMC), the young and elderly and those with a compromised immune system. The disease-causing viruses are small, each one consisting of the viral genome enclosed within a protein capsid comprised mostly of the major viral structural protein VP1. This is a key protein in virus replication. It is responsible for the delivery of the virus genome to start an infection and production of more virus to spread infection both between cells and between people. Importantly, as the major constituent of viral capsids, VP1 is important for generating an anti-viral immune response and is the first viral component the immune system experiences during when a person become infected. This research will study how VP1 functions at different steps of the virus life-cycle to start infection and spread infection to new cells. Understanding these fundamental processes will aid the development of future approaches to disease control. |
| Category | Fellowship |
| Reference | MR/S007229/1 |
| Status | Closed |
| Funded period start | 01/01/2019 |
| Funded period end | 31/03/2025 |
| Funded value | £1 281 714,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FS007229%2F1 |
Participating Organisations
| University of Leeds | |
| University of Michigan | |
| University of Southampton |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Leeds, LS2 9JT Leeds, Royaume Uni.
