Moteur de recherche d’entreprises européennes
UK funding : PRÉVENTION DE LÉSIONS PULMONAIRES ASSOCIÉES À UN VENTILATEUR À L’AIDE DE L’INGÉNIERIE DE CONTRÔLE PAR RÉTROACTION Ukri01/03/2010 UK Research and Innovation, Royaume Uni
Vue d’ensemble
Texte
PRÉVENTION DE LÉSIONS PULMONAIRES ASSOCIÉES À UN VENTILATEUR À L’AIDE DE L’INGÉNIERIE DE CONTRÔLE PAR RÉTROACTION
| Abstract | This project will develop a multi-compartmental, multi-scalar, mathematical model of alveolar ventilation dynamics (which includes gas exchange, dynamic and non-linear alveolar compliance and bronchial resistance), cardiovascular performance and blood (with reference to its gas-carrying abilities). The developed model will be used to elucidate the extent and distribution of the factors causative of lung injury in diseased, heterogeneous, mechanically-ventilated lungs. By treating the problem as one of feedback control, we will investigate methods of parameter adjustment in the mechanical ventilator to optimise cardiac output and arterial gas tensions while minimising the factors associated with VALI. Due to the inevitable complexity of the simulation model which we intend to develop, advanced methods from multivariable robust and optimal control theory will be required in order to identify which combinations of parameters should be adjusted, and how, in order to achieve the desired reduction in VALI. The work will go beyond that previously attempted in quantifying the factors that risk lung injury during mechanical ventilation through the greater fidelity of the proposed simulation platform. In addition, we will apply robustness analysis techniques to the modelling to improve the reliability and applicability of our findings. This will allow us to perform population modelling, rather than the commonly used approach of modelling and studying a single, idealized subject, rendering our findings applicable to populations and to a variety of real patients, in contrast to previous work where the idealized subject is in fact representative of neither the population nor any one individual. |
| Category | Research Grant |
| Reference | EP/F057016/2 |
| Status | Closed |
| Funded period start | 01/03/2010 |
| Funded period end | 31/10/2011 |
| Funded value | £0,00 |
| Source | https://gtr.ukri.org/projects?ref=EP%2FF057016%2F2 |
Participating Organisations
| UNIVERSITY OF EXETER |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University OF Exeter, Exeter, Royaume Uni.
Les visualisations de "University of Exeter - UK funding : PRÉVENTION DE LÉSIONS PULMONAIRES ASSOCIÉES À UN VENTILATEUR À L’AIDE DE L’INGÉNIERIE DE CONTRÔLE PAR RÉTROACTION"
sont mis à disposition par
North Data
et peuvent être réutilisées selon les termes de la licence
Creative Commons CC-BY.
