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UK funding (359 267 £) : Manipulation des voies de réplication/recombinaison/réparation de l’ADN des plastes pour étudier le maintien du génome des plastes et améliorer les technologies … Ukri01/08/2011 UK Research and Innovation, Royaume Uni
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Manipulation des voies de réplication/recombinaison/réparation de l’ADN des plastes pour étudier le maintien du génome des plastes et améliorer les technologies transplastomiques dans les cultures.
| Abstract | Chloroplasts contain the green pigment chlorophyll and are microscopic components of plant cells. They are responsible for photosynthesis and convert carbon dioxide into organic living material. These centres of photosynthesis carry out many vital plant functions and are essential for plant productivity and the performance of crops. Chloroplasts are especially interesting because they contain a small but very important set of genes that are very different from the set of genes organised as chromosomes in the nucleus of cells. These genes are essential for chloroplasts to function but were difficult to study until relatively recently. Transplastomics is a new field of research that allows the genes in chloroplasts to be studied directly and will allow improvements to chloroplast genes that enhance plant productivity in a changing environment. These transplastomic studies have shown that chloroplast genes have a number of desirable features. They code for important proteins that are amongst the most abundant proteins found in leaves and they are not spread through pollen. Moreover transplastomic technologies are extremely precise in enabling targeted improvements to chloroplast genes. Transplastomic technologies allow chloroplasts to be used as solar energy convertors which are a carbon efficient and sustainable manufacturing platform for producing useful biomolecules. Genes are made of DNA and they are maintained by molecular machines that replicate and repair them. The genes in chloroplasts are continually damaged by the action of sunlight. Efficient repair and replication is required to maintain functional chloroplast genes. We are studying the molecular machines responsible for maintaining chloroplast genes by removing specific components of the machines and then examining the impact of their removal on the maintenance of chloroplast genes. Our results have identified key components and molecular mechanisms required for maintaining chloroplast genes. Whilst much progress has been made using transplastomic technologies, a current limitation is their efficiencies particularly in important crops such as oil seed rape. In this research we will exploit our knowledge of the gene maintenance machinery in chloroplasts to improve the efficiency of transplastomic methods. This will allow the benefits of transplastomic research to be realised in important crops. This work will also provide new knowledge on the molecular processes that maintain the integrity of chloroplast genes. Because this process is important for plant growth and development it will improve our understanding of a key molecular process required for plant productivity. |
| Category | Research Grant |
| Reference | BB/I011552/1 |
| Status | Closed |
| Funded period start | 01/08/2011 |
| Funded period end | 31/07/2014 |
| Funded value | £359 267,00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FI011552%2F1 |
Participating Organisations
| The University of Manchester | |
| Protein Technologies Ltd |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : The University of Manchester, Manchester, Royaume Uni.
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