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UK funding (374 823 £) : L’inflammation et le microenvironnement tumoral dans le cancer du sein : le rôle de Stat3 et de NF-kB Ukri01/06/2010 UK Research and Innovation, Royaume Uni
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L’inflammation et le microenvironnement tumoral dans le cancer du sein : le rôle de Stat3 et de NF-kB
| Abstract | Breast cancer is a common disease in post-menopausal women. Although surgery and chemotherapy prolong life, many breast tumours spread to other organs and this metastatic disease causes the death of the patient. There is evidence from epidemiological studies that, although pregnancy can reduce the lifetime risk of breast cancer, women have a higher risk in the 5-10 years following a pregnancy. We propose that this risk is due to the factors that are present in the breast during the period immediately following lactation (involution), when the milk-producing cells die and secrete a number of inflammatory substances. Our studies on the processes that take place during involution have identified some of these factors. In this project, we propose to delete two signaling molecules that are key regulators of involution and measure the effect this has on tumour formation in models of breast cancer. Once we have identified the most important factors, we will compare levels of these in cell lines derived from breast cancer tissues. We will then specifically block these factors in breast cancer cells and measure how this affects their growth and spread in a novel tissue scaffold that we are developing to provide a 3-D model of the breast. It is hoped that this work will reveal new therapeutic targets or markers of breast cancer. |
| Category | Research Grant |
| Reference | G0900980/1 |
| Status | Closed |
| Funded period start | 01/06/2010 |
| Funded period end | 30/09/2013 |
| Funded value | £374 823,00 |
| Source | https://gtr.ukri.org/projects?ref=G0900980%2F1 |
Participating Organisations
| University of Cambridge |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Cambridge, Cambridge, Royaume Uni.
