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Financement de l’UE (1 500 000 €) : Les difficultés pour que la vie devienne grande – repenser l’hypoxie comme moteur de l’évolution de l’essor de la multicellularité complexe Hor16/09/2020 Programme de recherche et d'innovation de l'UE « Horizon »
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Les difficultés pour que la vie devienne grande – repenser l’hypoxie comme moteur de l’évolution de l’essor de la multicellularité complexe
Why complex life evolved on Earth has puzzled scientists for as long as sufficient oxygen has been deemed vital. Motivated by recent discoveries, however, this project will investigate the dawning paradox that multicellular life requires low oxygen (hypoxia) internally to thrive in the oxic niche. Central biological mechanisms in animals and plants need protection from oxygen and appears to depend on hypoxic niches. I have previously reconciled geological and medical observations to demonstrate how biological innovation to harness hypoxia would have allowed animals to conquer the previously inaccessible oxic niche. Although life must have invented several solutions to the paradox, the only known is the recent Nobel Prize-awarded mechanism of how cells sense oxygen. Earth history can uniquely evaluate its evolutionary importance through a geologic lens. In ParadOX, I propose to build a transdisciplinary team that provides a novel geobiological evaluation of the role of innovations that harness hypoxia and the processes that led to them. ParadOX will: 1) Experimentally define a) Paleozoic oxygenation as kill-mechanism for species with limited access to hypoxia b) Role of hypoxia for invertebrate longevity and life cycle 2) Theoretically explore a) Changes in Neoproterozoic shelf area and daily O2 fluctuations as drivers of hypoxia-machineries b) Co-evolution of hypoxia-machineries in animals and plants The project uniquely integrates knowledge from geology, biology, medicine, and numerical modeling. ParadOX’s inquiries groundbreakingly shift our perspective from a simplistic to a dualistic view on the role of oxygen for complex life. Insight to the evolutionary importance and processes that underpin biological innovations to harness hypoxia will advance our view on the rise of multicellularity on Earth, on other planets, and even within us as tumor multicellularity. ParadOX opens a new horizon of investigations into the drivers and the hardships of complex life.
| Lunds Universitet | 1 500 000 € |
https://cordis.europa.eu/project/id/949538
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Lunds universitet Statliga enheter, Lund, Suède.
