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Financement de l’UE (166 320 €) : Stimulation acoustique en boucle fermée pendant le sommeil pour améliorer la consolidation de la mémoire motrice dans le vieillissement Hor 07/08/2020 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Stimulation acoustique en boucle fermée pendant le sommeil pour améliorer la consolidation de la mémoire motrice dans le vieillissement
Research has consistently demonstrated that older adults have difficulties consolidating recently learned movements into robust motor memories. This impairment undoubtedly contributes to the movement deficits emerging with healthy aging and hinders rehabilitative strategies. As consolidation is known to be facilitated by sleep, these movement-related deficits partially result from age-associated degradations in sleep characteristics. Accordingly, the project CLASSy Aging (Closed-Loop Acoustic Stimulation during Sleep to enhance motor memory consolidation in Aging) aims to optimize sleep-related motor memory consolidation in healthy older adults. Specifically, during a post-learning nap, I will use forefront real-time electroencephalographic (EEG) analyses to reactivate memories via Targeted Memory Reactivation time-locked to neuroplasticity-related physiological events of interest (i.e., sleep spindles and slow oscillations). This project will use a novel and sophisticated approach designed to boost sleep-dependent consolidation and minimize previously observed aging-related deficits. I will unravel the neural correlates of the memory reactivation process using high-density EEG during post-learning sleep and the stimulation-enhanced neuroplasticity processes during task practice using functional Magnetic Resonance Imaging (MRI). This project uses a comprehensive approach as the brain will be imaged at different phases of the memory formation (i.e., learning, consolidation and retest) making use of cutting-edge neuroimaging analyses (univariate and multivariate MRI analyses, sources localization of hdEEG signal) tailored to each of these phases. This ambitious, yet feasible, multimodal neuroimaging project will provide significant insights into motor memory processes. It will offer new avenues to amplify neuroplasticity, alleviate motor deficits, and increase well-being in not only healthy aging, but ultimately in those with neurological conditions.
| Katholieke Universiteit Leuven | 166 320 € |
https://cordis.europa.eu/project/id/887955
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Katholieke Universiteit te Leuven, Leuven, Belgique.
