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UK funding (630 732 £) : L’impact des helminthes sur les allergies : interactions régulatrices et mécanismes de protection dans l’inflammation des voies respiratoires Ukri11/12/2006 UK Research and Innovation, Royaume Uni
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L’impact des helminthes sur les allergies : interactions régulatrices et mécanismes de protection dans l’inflammation des voies respiratoires
| Abstract | Helminth parasites are worms that can evade the body‘s natural defences, exploiting an ‘Achilles heel‘ in our immune system. Certain helminths exploit so-called ‘regulatory cells‘, whose role is to stop the immune system from attacking the body‘s own proteins or from attacking harmless environmental molecules. By expanding the regulatory cells, the parasites not only disable the immune response to themselves, but dampen reactions to other ‘bystander’ proteins such as allergens from house dust mite. In this project, we propose to test whether this effect provides a long-lasting protection against infection, or is lost on treatment to remove parasites; to analyse the cells and molecules involved in inhibiting allergy in the airways, using an animal model for asthma; and to test whether the presence of the parasite can switch potentially damaging allergen-reactive cells into becoming regulatory cells themselves. As a result of this research, we may be able to develop new therapeutic strategies, borrowed from the parasites, to treat allergies and other immune-related diseases. |
| Category | Research Grant |
| Reference | G0501474/1 |
| Status | Closed |
| Funded period start | 11/12/2006 |
| Funded period end | 10/12/2009 |
| Funded value | £630 732,00 |
| Source | https://gtr.ukri.org/projects?ref=G0501474%2F1 |
Participating Organisations
| University of Edinburgh |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Edinburgh, Edinburgh, Royaume Uni.