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Financement de l’UE (2 498 419 €) : Puce acoustofluidique à couche mince pour la séparation des exosomes du sang Hor17/11/2022 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Puce acoustofluidique à couche mince pour la séparation des exosomes du sang
AcouSome is a consortium stemming from the ongoing EIC-FET Open BioWings project, and consists of four of the BioWings project partners (AcouSort AB, DTU, Lund University and Day One Srl). AcouSome has the ambition to build on the disruptive technology of thin film actuated acoustofluidics developed in BioWings. The results obtained in BioWings will be combined with a polymer acoustofluidics technology developed in the ongoing Eurostars AcouPlast project to fabricate a polymer-based microfluidic chip for separating and enriching exosomes from blood for use in the next generation of point-of-care diagnostics. Exosomes are nano-sized extracellular vesicles that are released by a significant number of different cell types. They are considered an important biomarker, with high diagnostic potential in a wide range of diseases, including different kinds of cancer (glioblastoma, melanoma, prostate cancer and many others), hepatitis, kidney, cardiovascular and liver diseases. Therefore, there is an increasing interest in exosomes as a powerful diagnostic tool. Having the opportunity to isolate and analyze exosomes from a routine blood test is crucial for early detection of a wide range of diseases. In the AcouSome chip exosomes will be separated and enriched from blood by combining two steps already developed by Lund University and AcouSort. First plasma will be separated from blood by flowing the blood through a microfluidic channel, pushing the cells towards the centerline of the channel using ultrasoundand and subsequently splitting the cell and plasma flows. Exosomes will then be trapped and enriched from the plasma flow using a localized acoustic field. The acoustofluidic chip will be driven using thin-film actuators as invented together with DTU in the BioWings project. The exosome separation cartridge is intended for sample preparation in research labs and future diagnostic point-of-care instruments.
| Acousort AB | 1 145 000 € |
| Danmarks Tekniske Universitet | 818 419 € |
| Day ONE Srl | 210 000 € |
| Lunds Universitet | 325 000 € |
https://cordis.europa.eu/project/id/101099787
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.