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UK funding (130 705 £) : Modification de la morphologie et de l’arythmogénicité de l’infarctus par modulation péri-infarctus de la fonction jonctionnelle lacunaire Ukri01/10/2009 UK Research and Innovation, Royaume Uni
Vue d’ensemble
Texte
Modification de la morphologie et de l’arythmogénicité de l’infarctus par modulation péri-infarctus de la fonction jonctionnelle lacunaire
| Abstract | Ventricular arrhythmias (life-threatening heart rhythm disturbances) are responsible for the majority of 100,000 annual sudden deaths in the UK. Following a heart attack (myocardial infarction), the surviving heart muscle undergoes multiple changes during the healing process that subsequently predispose to these ventricular arrhythmias. One such change involves gap junctions, which are proteins that connect individual heart muscle cells. They are responsible for regular transmission of electrical impulses through the heart muscle and for maintenance of regular heart rhythm. Abnormal changes in gap junctions, termed gap junction remodelling, have been shown to occur in the healing process after myocardial infarction, and is associated with ventricular arrhythmias. We will assess if administering pharmacological agents that modify gap junctional function during the crucial time-window around an episode of myocardial infarction in rats, can influence the healing process by beneficially modifying the process of gap junction remodelling, thereby fundamentally reducing the risk of developing ventricular arrhythmias in the long-term. If results are positive, these pharmacological agents may be introduced into clinical practice. The prospect of a short-term treatment given at the time of myocardial infarction that provides lasting protection from lethal arrhythmias is compelling, intriguing, and accords with the concept of an ideal treatment. |
| Category | Fellowship |
| Reference | G0900396/1 |
| Status | Closed |
| Funded period start | 01/10/2009 |
| Funded period end | 30/09/2011 |
| Funded value | £130 705,00 |
| Source | https://gtr.ukri.org/projects?ref=G0900396%2F1 |
Participating Organisations
| Imperial College London |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Imperial College of Science Technology and Medicine, Londres, Royaume Uni.
