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UK funding (290 262 £) : Développement d’une nouvelle méthode pour l’évaluation détaillée des schémas de flux sanguin dans les segments de stent et l’évaluation de leur rôle dans la thrombose du stent Ukri01/03/2024 UK Research and Innovation, Royaume Uni
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Développement d’une nouvelle méthode pour l’évaluation détaillée des schémas de flux sanguin dans les segments de stent et l’évaluation de leur rôle dans la thrombose du stent
| Abstract | Stents are used today to treat the blockages of the vessels of the heart in patients who have angina or suffered a heart attack. In most of these patients, stent treatment is effective and improves symptoms and life expectancy. However, there is a small proportion of patients where the stents fail and block, causing either death or a major heart attack. Studies in animals have shown that the blood flow patterns following stent implantation can predict stents that are at risk to block. However, there is lack of data about the role of blood flow on stent blockage in humans. This is because it is very difficult to create models of the vessels of the heart that have been treated with stents. This study aims to address this problem. We will analyse images of the vessels of the heart taken by a wire that is advanced in these vessels. In these images we can see details of the vessel wall and of the stent. We will use these images to create models of the vessels treated with stents using a new method that we have developed and then we will simulate blood flow in these models to assess the flow patterns. We will do that at scale in 120 patients of whom 40 had a heart attack because of a blocked stent. We will then compare the flow patterns in stents that blocked and caused a heart attack and in vessels treated with stents that did not cause an event. We believe that this research will allow us to identify the flow patterns that can cause stent blockage. This information is important as it will help us to improve the design of future stents and also the way that we put stents so as to reduce the risk of stent blockage and future heart attacks. |
| Category | Research Grant |
| Reference | MR/X009068/1 |
| Status | Active |
| Funded period start | 01/03/2024 |
| Funded period end | 28/02/2026 |
| Funded value | £290 262,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FX009068%2F1 |
Participating Organisations
| Queen Mary University of London | |
| MedStar Health Research Institute | |
| Medical University of Warsaw | |
| King's College Hospital NHS Foundation Trust (NCH) | |
| University Hospital La Princesa | |
| McMaster University | |
| OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST | |
| Columbia University | |
| Nara University | |
| National Heart Centre Singapore | |
| Fujita Health University | |
| LEEDS TEACHING HOSPITALS NHS TRUST | |
| San Carlos University Hospital | |
| UNIVERSITY HOSPITALS SUSSEX NHS FOUNDATION TRUST | |
| MANCHESTER UNIVERSITY NHS FOUNDATION TRUST | |
| University of Galway | |
| Shinshu University | |
| San Giovanni Addolorata Hospital | |
| ROYAL FREE LONDON NHS FOUNDATION TRUST | |
| Queen Elizabeth Hospital Birmingham | |
| Radboud University Nijmegen Medical Center | |
| UNIVERSITY HOSPITALS BRISTOL AND WESTON NHS FOUNDATION TRUST | |
| NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST | |
| Harbin Medical University | |
| Yonsei University | |
| Yale University | |
| Liverpool Heart and Chest Hospital NHS Foundation Trust | |
| Erasmus MC | |
| John Radcliffe Hospital | |
| MedStar Georgetown University Hospital | |
| Leiden University | |
| ASST Papa Giovanni XXIII Hospital | |
| Univ Hosp Bristol & Weston NHS Fdn Trust | |
| Royal Free London NHS Foundation Trust |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Queen Mary University of London, Londres, Royaume Uni.
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