Moteur de recherche d’entreprises européennes
Financement de l’UE (5 049 876 €) : Les ultrafines dérivées du transport et les effets cérébraux Hor01/05/2019 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Les ultrafines dérivées du transport et les effets cérébraux
The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.
| Biotalentum Tudasfejleszto kft. | 361 875 € |
| Centro Premio Nobel Mario Molina Para Estudios Estrategicos Sobre Energia Y Medio Ambiente Chile S.p.A. | 98 750 € |
| Ilmatieteen Laitos | 220 000 € |
| ITA-Suomen Yliopisto | 722 174 € |
| IUF - Leibniz-Institut FUR Umweltmedizinische Forschung GmbH | 403 040 € |
| Kobenhavns Universitet | 294 467 € |
| Mimetas B.V. | 400 393 € |
| Rijksinstituut Voor Volksgezondheid EN Milieu | 92 492 € |
| SUN YAT-SEN University | 0,00 € |
| Tampereen Korkeakoulusaatio sr | 337 087 € |
| Teknologian Tutkimuskeskus VTT Oy | 520 086 € |
| Umea Universitet | 262 625 € |
| Universita Degli Studi Di Verona | 168 996 € |
| Universiteit Utrecht | 486 364 € |
| University of Southampton | 232 868 € |
| Ustav Experimentalni Mediciny Akademie Ved Ceske Republiky Verejna Vyzkumna Instituce | 337 772 € |
| Vsparticle B.V. | 110 887 € |
https://cordis.europa.eu/project/id/814978
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.