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Financement de l’UE (8 808 363 €) : Boîte à outils avancée pour un criblage métagénomique fonctionnel rapide et rentable - la microbiologie rencontre la microfluidique. Hor11/05/2016 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Boîte à outils avancée pour un criblage métagénomique fonctionnel rapide et rentable - la microbiologie rencontre la microfluidique.
Metagenomes comprise enormous reservoirs coding for proteins with useful activities. Unfortunately, harvesting this reservoir is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Screening campaigns of metagenomic libraries thus require massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users. To enable valorisation of the potential of the metagenome, this project assembles an interdisciplinary and intersectoral consortium that will integrate a range of technologies into a platform designed to beat the odds of identifying library hits faster, more efficiently and by a wider user base. Exploration and exploitation of the metagenome will be made faster and more successful by (i) ultrahigh-throughput screening in picoliter droplets that dramatically lowers the cost per assay to well below 0.01 cents and allows throughput of 10e7 assays per hour; (ii) workflows that streamline and increase the yield of library construction and functional expression and (iii) workflows for efficient bioinformatic analysis of hits based on user-friendly software solutions for metagenome analysis. Emphasis is put on technologies that are straightforwardly implemented in non-specialist labs, maximising the impact of METAFLUIDICS. This platform will be used to identify enzymes for biosynthesis of therapeutic small molecules, for green bioenergy conversion, bioremediation, food chemistry and other industrial applications
| Agencia Estatal Consejo Superior de Investigaciones Cientificas | 636 283 € |
| Bioiliberis Research And Development SL | 460 000 € |
| Centro de Neurociencias e Biologiacelular Associação | 407 590 € |
| Drop-Tech Ltd. | 207 820 € |
| Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement | 0,00 € |
| Institut National des Sciences Appliquees de Toulouse | 722 255 € |
| Instituto Nacional de Tecnica Aeroespacial Esteban Terradas | 0,00 € |
| Norges Teknisk-Naturvitenskapelige Universitet Ntnu | 840 358 € |
| Novozymes A/S | 821 729 € |
| Prozomix Ltd. | 546 806 € |
| Qiagen Aarhus AS | 463 750 € |
| Sintef AS | 461 247 € |
| Stiftelsen Sintef | 291 006 € |
| The Chancellor Masters and Scholars of the University of Cambridge | 1 120 190 € |
| Universidad Autonoma de Madrid | 1 233 729 € |
| Universidad de Alicante | 595 600 € |
https://cordis.europa.eu/project/id/685474
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.