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Financement de l’UE (4 944 348 €) : Bioélectronique adaptative pour les maladies cardiorespiratoires chroniques Hor 02/11/2016 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Bioélectronique adaptative pour les maladies cardiorespiratoires chroniques
This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.
| Fakultni Nemocnice U SV Anny V Brne | 102 250 € |
| Medizinische Universitaet Wien | 584 375 € |
| Medtronic Bakken Research Center B.V. | 550 000 € |
| Microchip Technology Caldicot Ltd. | 403 125 € |
| Universitair Medisch Centrum Utrecht | 490 625 € |
| Universitat Zurich | 833 368 € |
| University of Bath | 1 548 936 € |
| University of Bristol | 431 669 € |
https://cordis.europa.eu/project/id/732170
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.