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Financement de l’UE (12 M €) : Trajectoires dynamiques longitudinales des exposomes dans les maladies cardiovasculaires et métaboliques non transmissibles Hor01/01/2020 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Trajectoires dynamiques longitudinales des exposomes dans les maladies cardiovasculaires et métaboliques non transmissibles
Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. The extent to which these exposures may cause their attributed health effects (via molecular mediation) directly or indirectly as a result of associations to an individual’s psychosocial context is largely unknown. NCDs arise from a lifelong process influencing anthropometric, glycaemic, cardiac and lipid-related health trajectories. Risks may start as early as during the fetal period and are modified during sensitive periods in childhood, adolescence and adulthood. Despite this, research has not focused enough on the life-course characterisation of the exposome and the application of this to health and disease. In 5 years, LONGITOOLS, a partnership of 15 academic groups and 3 small companies will harness a catalogue of birth cohorts, longitudinal data, registers and biobanks. We will characterise coincident longitudinal trajectories of exposure and cardiometabolic health combining the study of longitudinal effects and internal responses. The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. LONGITOOLS will implement this longitudinal approach in 11 work packages designed to generate a catalogue of FAIR data and a novel analytical toolbox. Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. A key objective will be to generate evidence-based predictions which can ultimately translate into innovative healthcare applications (apps) and policy options. LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. LONGITOOLS is one of the nine projects composing the European Human Exposome Network.
| AB.Acus Srl | 574 125 € |
| Academisch Ziekenhuis Groningen | 600 625 € |
| Beta Technology Ltd. | 647 870 € |
| Chalmers Tekniska Hogskola AB | 427 941 € |
| Cynexo Srl | 372 955 € |
| Erasmus Universitair Medisch Centrum Rotterdam | 896 160 € |
| Imperial College of Science Technology and Medicine | 796 910 € |
| Institut National de la Sante et de la Recherche Medicale | 451 375 € |
| ITA-Suomen Yliopisto | 987 595 € |
| Oulun Yliopisto | 1 171 875 € |
| Stichting Amsterdam UMC | 552 321 € |
| Universita Degli Studi Di Roma TOR Vergata | 555 125 € |
| Universitat de Barcelona | 716 250 € |
| Universiteit Utrecht | 524 258 € |
| Universitetet I Oslo | 500 943 € |
| University College London | 729 781 € |
| University of Bristol | 808 993 € |
| University of Surrey | 682 348 € |
https://cordis.europa.eu/project/id/874739
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.
