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Financement de l’UE (6 807 868 €) : Connecter les réseaux neuronaux : la technologie du système nerveux sur puce Hor 16/11/2018 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Connecter les réseaux neuronaux : la technologie du système nerveux sur puce
Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model in Parkinson’s Disease. This provides CONNECT with novel insights, thereby paving the way for future development of therapeutic strategies.
| Aalto Korkeakoulusaatio sr | 903 680 € |
| Erasmus Universitair Medisch Centrum Rotterdam | 842 500 € |
| Ffund B.V. | 176 250 € |
| Katholieke Universiteit Leuven | 953 125 € |
| Technische Universiteit Eindhoven | 1 675 000 € |
| The University of Sheffield | 1 010 308 € |
| Universite Du Luxembourg | 1 247 005 € |
https://cordis.europa.eu/project/id/824070
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.