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Financement de l’UE (7 948 503 €) : Ingénierie guidée par la biologie synthétique de Pseudomonas putida pour la biofluoration Hor01/01/2019 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Ingénierie guidée par la biologie synthétique de Pseudomonas putida pour la biofluoration
Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.
| Agencia Estatal Consejo Superior de Investigaciones Cientificas | 443 965 € |
| Altar | 302 560 € |
| Biofaction KG | 385 269 € |
| Bioplastech Ltd. | 965 104 € |
| Chemours Netherlands B.V. | 0,00 € |
| Danmarks Tekniske Universitet | 2 394 408 € |
| Ifeu - Institut FUR Energie-UND Umweltforschung Heidelberg gGmbH | 373 000 € |
| IN Srl | 577 682 € |
| Masarykova Univerzita | 435 288 € |
| MAX-Planck-Gesellschaft ZUR Forderung DER Wissenschaften e. V. | 568 389 € |
| Tartu Ulikool | 390 000 € |
| The University Court of the University of St Andrews | 481 250 € |
| Universite Du Luxembourg | 631 590 € |
https://cordis.europa.eu/project/id/814418
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.
