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Financement de l’UE (6 388 104 €) : Un nouvel algorithme de médecine stratifiée pour prédire les réponses au traitement dirigé par l’hôte chez les patients tuberculeux. Hor01/01/2020 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Un nouvel algorithme de médecine stratifiée pour prédire les réponses au traitement dirigé par l’hôte chez les patients tuberculeux.
Tuberculosis (TB) is a chronic, life-threatening infectious disease which poses a tremendous challenge for physicians, researchers and Health Systems, which treatment is long, based only on the drug susceptibility of the responsible infective strain and very costly in drug-resistant cases (MDR-TB). The European Region still has the highest prevalence of MDR-TB in the world. Host-Directed Therapies (HDT) have been recently proposed to shorten treatment length and by to improve the patients’ outcomes while not increasing the risk of generating drug resistance. As hyperinflammation is responsible of the lung damage associated to patients’ worse outcomes and sequelae, one of the approaches is to add an HDT with anti-inflammatory effect to the current drug regimen to cure the patients faster while having less permanent lung damage. Because TB has a wide range of clinical forms and severity stages, any therapeutic regimen needs to be studied in clinical trials (CT) as its benefit might differ among patients. No individualized personalized medicine is possible without stratifying the patients by integrating pathogen and host factors that will predict the course of the disease and the response to the intervention. SMA-TB objectives are: • To evaluate in a CT the potential impact of acetylsalicylic acid (ASA) and Ibuprofen (Ibu) (anti-inflammatoriesy HDT) as adjuncts to standard therapy for drug sensitive (DS-) and MDR-TB. This potentially will reduce tissue damage, decrease the length of the treatment and the risk of bad outcomes. • To identify and clinically validate host and pathogen biomarkers for further selection according to their relevance in terms of their ability to predict TB course and outcomes and response to treatment thanks to data science protocol. • To generate a medical algorithm to stratify patients using network-based mathematical modelling for predicting the course of the disease and its response to the intervention, to be applied during clinical management to improve and personalize TB.
| Academisch Ziekenhuis Leiden | 612 564 € |
| Anaxomics Biotech SL | 428 250 € |
| Centre National de la Recherche Scientifique CNRS | 656 910 € |
| Institut de Investigacio en Ciencies de La Salut Germans Trias i Pujol | 1 679 625 € |
| Lionex GmbH | 124 905 € |
| National Center FOR Lung Health JSC | 599 141 € |
| Oslo Universitetssykehus HF | 840 125 € |
| Tes2A Europe Consulting And Business Development SL | 339 260 € |
| Wits Health Consortium (PTY) Ltd. | 1 107 324 € |
https://cordis.europa.eu/project/id/847762
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.