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Financement de l’UE (1 500 000 €) : Imagerie de circuits cérébraux pour décoder les calculs cérébraux : imagerie multimodale multi-échelle de microcircuits corticaux pour modéliser le codage … Hor01/06/2015 Programme de recherche et d'innovation de l'UE « Horizon »
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Texte
Imagerie de circuits cérébraux pour décoder les calculs cérébraux : imagerie multimodale multi-échelle de microcircuits corticaux pour modéliser le codage prédictif dans la vision humaine
The human brain is one of the largest and most complex biological networks known to exist. The architecture of its circuits, and therefore the computational basis of human cognition, remains largely unknown. The central aim of this proposal is to image human cortical connectivity at multiple spatial scales in order to understand human cortical computations. Whereas canonical cortical microcircuits are an established theory of the repeating structure of the neocortex’s circuits, predictive coding provides a prominent proposal of what these circuits compute. This leads to the core hypothesis of this proposal: the variations in predictive coding computations performed by human cortical microcircuits in different visual areas are grounded in variations in their microcircuit connectivity. As a central case-study, this proposal investigates human visual apparent motion perception in V1/2/3 and V5/MT+. The proposed research program is organized in two workpackages (WP I and II). WP I has the aim of imaging the multiscale connections of human neocortical microcircuits. The projects in WP I focus on structure and move from the mesoscale down to the microscale. WP II has the aim of modelling how microcircuits support predictive coding computations. The projects in WP II focus on function and move from the microscale back up to the mesoscale. Structural and functional assessment of microcircuitry in the human brain only recently became possible with the development of magnetic resonance imaging (MRI) at ultra-high field-strengths (UHF) of 7T and above. UHF diffusion MRI, combined with light microscopy, is used to image circuit structure in WP I. UHF functional MRI is used for computational modelling of computations in WP II. Successful completion of the planned research will significantly advance our understanding of the computations in cortical microcircuits, deliver important new human connectomic reference data, and improve generative models of human cortical processing.
| UNIVERSITEIT MAASTRICHT | 1 500 000 € |
https://cordis.europa.eu/project/id/639938
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Universiteit Maastricht, Maastricht, Pays-Bas.
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