Moteur de recherche d’entreprises européennes
Financement de l’UE (12,7 M €) : Outils physiologiquement ancrés pour une évaluation réaliste des risques nanomatériels Hor01/01/2018 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Outils physiologiquement ancrés pour une évaluation réaliste des risques nanomatériels
Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.
| BASF SE | 684 843 € |
| Consiglio Nazionale Delle Ricerche | 441 845 € |
| Danmarks Tekniske Universitet | 821 238 € |
| DET Nationale Forskningscenter FOR Arbejdsmiljø | 758 366 € |
| EUROPEAN RESEARCH SERVICES GmbH | 311 250 € |
| HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES Inc. | 0,00 € |
| Heriot-Watt University | 1 166 364 € |
| INSPHERO AG | 481 961 € |
| Institute of Occupational Medicine | 370 816 € |
| IUF - LEIBNIZ-INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG GmbH | 597 253 € |
| Korea Research Institute OF Standards AND Science | 0,00 € |
| MISVIK BIOLOGY Oy | 336 325 € |
| Nanotechnology Industries Association | 251 469 € |
| Qsar Lab sp. z o.o. | 353 194 € |
| RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU | 881 765 € |
| Swansea University | 1 511 624 € |
| The University of Exeter | 590 886 € |
| United Kingdom Research and Innovation | 88 656 € |
| Universita Di Pisa | 384 930 € |
| Universite Catholique de Louvain | 428 826 € |
| UNIVERSITE DE FRIBOURG | 863 390 € |
| Universite de Namur | 538 713 € |
| UNIVERSITEIT LEIDEN | 850 468 € |
| UNIVERSITY OF SOUTH CAROLINA | 0,00 € |
https://cordis.europa.eu/project/id/760813
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.