Moteur de recherche d’entreprises européennes
Financement de l’UE (2 814 491 €) : Sonder l’innocuité des nano-objets en définissant les réponses immunitaires des organismes environnementaux Hor 27/08/2015 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Sonder l’innocuité des nano-objets en définissant les réponses immunitaires des organismes environnementaux
PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.
| Alta Ricerca E Sviluppo IN Biotecnologie Srlu | ? |
| AvantiCell Science Ltd. | 273 288 € |
| Cardiff University | 273 288 € |
| Consiglio Nazionale Delle Ricerche | 516 123 € |
| Eberhard Karls Universitaet Tuebingen | 249 216 € |
| Fundacio Institut Catala de Nanociencia i Nanotecnologia | 247 873 € |
| Mikrobiologicky Ustav AV CR V.V.I | 232 422 € |
| Paris-Lodron-Universitat Salzburg | 255 934 € |
| UK Centre for Ecology & Hydrology | 159 418 € |
| United Kingdom Research and Innovation | 113 870 € |
| Universita Degli Studi Di Genova | 258 061 € |
| Univerza V Ljubljani | 234 998 € |
https://cordis.europa.eu/project/id/671881
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Alta Ricerca E Sviluppo IN Biotecnologie Srlu, Siena, Italie.