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Financement de l’UE (10,9 M €) : Cartographie des effets immunitaires induits par l’exposition : relier l’exposome et l’immunome Hor01/01/2020 Programme de recherche et d'innovation de l'UE « Horizon »
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Cartographie des effets immunitaires induits par l’exposition : relier l’exposome et l’immunome
Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed. The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and -profiling platforms to map the (early) immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will extensively map exposome, immune system (immunome), other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyse these huge datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at the individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to grasp the components of the exposome that needs to be prioritized to be able to design targeted preventive policies to reduce healthcare and socioeconomic costs, leading to greater wellbeing for the EU population. EXIMIOUS will work together with the other projects (EXPANSE, HEAP, ATHLETE, EQUAL-LIFE, LONGITOOLS, EPHOR, REMEDIA and HEDIMED) funded within the Human Exposome programme call H2020-SC1-BHC-2018-2020, in order to achieve collaboration and synergy.
| Aarhus Universitet | 67 150 € |
| ACCELOPMENT SCHWEIZ AG | 221 890 € |
| Belgian Center for Occupational Hygiene | 911 271 € |
| Biogenity ApS | 180 850 € |
| DET Nationale Forskningscenter FOR Arbejdsmiljø | 664 875 € |
| Folkehelseinstituttet | 1 336 685 € |
| Fundacio Hospital Universitari Vall D'Hebron - Institut de Recerca | 395 500 € |
| Interuniversitair Micro-Electronica Centrum | 461 025 € |
| Katholieke Universiteit Leuven | 4 130 715 € |
| Region Hovedstaden | 172 000 € |
| The Babraham Institute | 111 438 € |
| The Chancellor Masters and Scholars of the University of Cambridge | 144 812 € |
| The Queen's University of Belfast | 158 458 € |
| Universitatea de Medicina, Farmacie, Stiinte si Tehnologie George Emil Palade Din Targu Mures | 771 438 € |
| Universite Catholique de Louvain | 549 500 € |
| Universiteit Hasselt | 600 725 € |
https://cordis.europa.eu/project/id/874707
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