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Financement de l’UE (6 223 330 €) : Intégrer l’épidémiologie et la biologie expérimentale pour améliorer l’évaluation des risques d’exposition à des mélanges de composés perturbateurs endocriniens Hor 01/05/2015 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Intégrer l’épidémiologie et la biologie expérimentale pour améliorer l’évaluation des risques d’exposition à des mélanges de composés perturbateurs endocriniens
A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.
| Centre National de la Recherche Scientifique CNRS | 428 436 € |
| Ethniko Kai Kapodistriako Panepistimio Athinon | 321 250 € |
| Goeteborgs Universitet | 316 750 € |
| Icahn School OF Medicine AT Mount Sinai | 265 570 € |
| Istituto Europeo Di Oncologia Srl | 489 000 € |
| Karlstads Universitet | 1 194 481 € |
| Karolinska Institutet | 1 089 181 € |
| Lunds Universitet | 585 000 € |
| Museum National d'Histoire Naturelle | 0,00 € |
| Orebro University | 252 030 € |
| Stockholms Universitet | 450 061 € |
| Terveyden JA Hyvinvoinnin Laitos | 350 538 € |
| Universitaet Leipzig | 62 500 € |
| Uppsala Universitet | 418 533 € |
https://cordis.europa.eu/project/id/634880
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