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Financement de l’UE (2 965 326 €) : Early Detection of cancer onset based on sensing field cancerization at the organ level Hor28/06/2018 Programme de recherche et d'innovation de l'UE « Horizon »
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Early Detection of cancer onset based on sensing field cancerization at the organ level
Cancer is a major cause of death worldwide. Gastrointestinal (GI) tract tumors are among the most common and deadliest ones. Despite progress in imaging and treatment, the social impact of these diseases is enormous. All parties in the health sector agree that prevention and/or early diagnosis is the most effective means to deal with cancer. Currently, cancer is identified most often when symptomatic or large enough to be visualized in body scans or when histological alterations are already present. What is lacking is an imaging method that could detect tissue changes that facilitate or predict tumor development at an early stage. These alterations, collectively referred to as “field cancerization” is an exciting field of study in cancer biology with profound ramifications in clinical practice. Molecular mechanisms underlying field cancerization are being studied and the advances in molecular biology facilitate these studies. Never in the past however, have these changes been sensed/measured by an imaging modality at the organ level. We thus propose the development of a multimodal microscopy platform that will allow sensing of Raman and scattering properties at the organ level, in order to identify molecular and structural fingerprints of early stage disease in the GI tract. Successful implementation will allow the development of an endoscope especially designed for this purpose that will be used to detect early stage cancer in humans.
| ACADEMISCH ZIEKENHUIS GRONINGEN | 438 781 € |
| Exelixis Diacheirisi Erevnas Kai Epikoinonia ΕΕ | 134 625 € |
| HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GmbH | 697 876 € |
| Idryma Iatroviologikon Ereunon Akademias Athinon | 541 813 € |
| Rayfos Ltd. | 231 919 € |
| RIVERD INTERNATIONAL B.V. | 558 125 € |
| Universidad Carlos III de Madrid | 362 188 € |
https://cordis.europa.eu/project/id/801347
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