Moteur de recherche d’entreprises européennes
Financement de l’UE (3 860 843 €) : Une approche interdisciplinaire intégrée de l’évaluation de la sécurité des produits chimiques et des nanomatériaux exempts d’animaux Hor 26/09/2016 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Une approche interdisciplinaire intégrée de l’évaluation de la sécurité des produits chimiques et des nanomatériaux exempts d’animaux
All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.
| European Society of Toxicology in Vitro | ? |
| Biotalentum Tudasfejleszto kft. | 223 914 € |
| Department of Health | 273 288 € |
| Edelweiss Connect GmbH | 265 227 € |
| Evercyte GmbH | 255 934 € |
| Istituto Di Ricerche Farmacologiche Mario Negri | 516 123 € |
| Katholieke Universiteit Leuven | 250 560 € |
| Kemijski Institut | 234 998 € |
| Liverpool John Moores University | 273 288 € |
| Medizinische Universitat Innsbruck | 0,00 € |
| Newcells Biotech Ltd. | 273 288 € |
| Stichting VU | 510 749 € |
| Universite d'Artois | 262 876 € |
| Universite DE Lausanne | 265 227 € |
| Universiteit Utrecht | 255 374 € |
https://cordis.europa.eu/project/id/721975
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : European Society of Toxicology in Vitro, Houten, Pays-Bas.
