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Financement de l’UE (224 934 €) : Quantification of Free and Bound Water Concentrations in Human Cortical Bone Employing Hybrid Hard-tissue MRI: Towards Comprehensive Osteoporosis Assessment Hor23/04/2020 Programme de recherche et d'innovation de l'UE « Horizon »
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Quantification of Free and Bound Water Concentrations in Human Cortical Bone Employing Hybrid Hard-tissue MRI: Towards Comprehensive Osteoporosis Assessment
Osteoporosis weakens bones and increases the risk of unexpected fractures. Worldwide, it causes over 8.9M fractures annually. Cortical bone consists of 3 major parts; minerals, organic matrix and water. Bone Mineral Density (BMD) is the most widespread marker to assess bone quality. There is recent evidence, however, that bone mineralisation offers only an incomplete view of bone quality. In turn, bone water (including free and bound water molecules) does convey richer information about bone quality by probing both bone porosity and the organic matrix. We propose to develop a novel diagnostic imaging technique based on Magnetic Resonance Imaging (MRI) that offers a comprehensive assessment of cortical bone quality and osteoporosis. The quantification of free and bound water molecules in cortical bone will be done in vivo as their alternation are potential biomarkers of the cortical bone quality. We will use hybrid hard-tissue MRI to capture information from short transverse-relaxation time (T2) species. We will develop MRI strategies that will go beyond the state-of-the-art in imaging bone tissue (herein referred to as “hard-tissue MRI” employing novel pulse sequences from the ultra-short echo-time (UTE) family. A key novelty lies in the hybridisation of UTE/short echo time (STE) acquisitions. By solving a set of coupled equations derived from these acquisitions using machine-learning techniques, we will define new quantitative imaging biomarkers associated with cortical bone free and bound water concentrations. The biomarkers will improve diagnosis of osteoporosis and alleviate its burden on healthcare systems (€37Bn cost to EU in 2010). It offers further potential in assessing bone development in pediatric imaging where ionizing and invasive methods cannot be employed. The project brings together expertise in bone MRI from a senior incoming fellow with the world-class expertise in biomedical image analysis and bone research as well as a pioneer centre in clinical.
| University of Leeds | 224 934 € |
https://cordis.europa.eu/project/id/898530
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Leeds, Leeds, Royaume Uni.
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