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Financement de l’UE (3 844 874 €) : Étude de la signalisation ciliaire dans le développement et la maladie Hor28/08/2019 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Étude de la signalisation ciliaire dans le développement et la maladie
SCilS will create a multidisciplinary and intersectoral European training network focusing on ciliary signalling in development and disease. Primary cilia are microtubule-based cell surface projections that have evolved to be key signalling hubs of our cells, as they concentrate or segregate components of major cellular signalling pathways. Control of ciliary signaling output requires a high degree of regulation and critical feedback, which is needed for robustness in development and cellular homeostasis of different tissues and organs. Dysfunctional cilia can therefore lead to >35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes. Ciliopathies affect as many as 1 in 400 people, and for the majority of cases efficient therapeutic interventions are currently unavailable. SCilS research aims to uncover the multi-level organization and regulation of cilia-mediated signalling pathways in order to understand ciliopathy disease etiology and identify novel therapeutic targets. This challenging task will be accomplished by integrating unique expertise and cutting edge technology available within the SCilS network, including structural biology, super resolution imaging and cryo-electron tomography, state-of-the-art genomics, proteomics and bioinformatics, (stem) cell biology and biochemistry, as well as organoid technology and zebrafish models. SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.
| Aarhus Universitet | 297 522 € |
| CELL NETWORKS GmbH | 252 788 € |
| EBERHARD KARLS UNIVERSITAET TUEBINGEN | 252 788 € |
| Imagine Institut des Maladies Genetiques Necker Enfants Malades Fondation | 549 604 € |
| Kobenhavns Universitet | 892 566 € |
| Newcells Biotech Ltd. | 303 173 € |
| Ospedale SAN Raffaele Srl | 261 500 € |
| RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG | 252 788 € |
| STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM | 531 240 € |
| STICHTING RADBOUD UNIVERSITEIT | 0,00 € |
| Zeclinics SL | 250 905 € |
https://cordis.europa.eu/project/id/861329
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.
