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Financement de l’UE (3 920 811 €) : Transport de protons et transport couplé de protons Hor 13/08/2019 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Transport de protons et transport couplé de protons
Secure, competitive, and sustainable energy production is a major challenge facing human societies. Biomimetic solutions such as the development of new biofuel cells are hampered by our thus far incomplete understanding of proton transfer reactions. The same holds for health threats to humanity: Curing diseases like cancer, obesity, chronic gastritis, gastric and duodenal ulcers, requires to pharmacologically interfere - in their molecular details - with yet unresolved proton transfer reactions. Here we aim at clarifying the molecular reaction mechanism in the confines of interfacial water layers and proteinaceous cavities with emphasis on arrangement and mobility of proton relay moieties. Achieving this requires an interdisciplinary, multi-level approach comprising cutting edge technologies like second harmonic imaging, single molecule and time resolved fluorescence microscopy and spectroscopy, advanced calculations of proton transfer, bioengineering of membrane channel and transporter containing systems, synthetic design of biomimetic proton channels, solving protein structures and rational drug design. PROTON will train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds of proton migration/reaction systems, covering from basic science to industrial applications, thus preparing them to generate new scientific knowledge of the highest impact. In addition, practical training on transferable skills will increase their employability and qualify them for responsible positions in private and public sectors. Cross-disciplinary strategies and close collaboration with industry will enable them to resolve the molecular details of proton driven processes in all kinds of settings - enabling the improvement of biomimetic applications – up to fuel cells - and to identify lead substances which may serve to pharmacologically interfere with proton transport through membrane channels and transporters.
| Boehringer Ingelheim Pharma GmbH & Co. KG | 252 788 € |
| Centre National de la Recherche Scientifique CNRS | 426 172 € |
| Christian-Albrechts-Universitaet ZU Kiel | 252 788 € |
| Ecole Polytechnique Federale DE Lausanne | 562 553 € |
| Freie Universitaet Berlin | 139 736 € |
| Heyrovskeho Ustav AV CR, v. v. i. | 364 247 € |
| Intana Bioscience GmbH | 252 788 € |
| THE Hebrew University OF Jerusalem | 263 501 € |
| Universitat DES Saarlandes | 252 788 € |
| Universitatea Din Bucuresti | 98 206 € |
| Universitat Linz | 528 414 € |
| Universitetet I Oslo | 262 621 € |
| Veterinaermedizinische Universitaet Wien | 264 207 € |
https://cordis.europa.eu/project/id/860592
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.