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Financement de l’UE (7 150 334 €) : Plateforme d’essais toxicologiques intégrant des modules in vitro/ex vivo immunocompétents avec détection en temps réel et apprentissage automatique basés sur des … Hor01/01/2024 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Plateforme d’essais toxicologiques intégrant des modules in vitro/ex vivo immunocompétents avec détection en temps réel et apprentissage automatique basés sur des modèles in silico pour l’analyse du cycle de vie et la SSbD
Safe and Sustainable by Design approach requires an entire life cycle monitoring of toxicity of chemicals. However, current testing systems cannot mimic the exposure conditions related to each step and are not compatible with downstream in silico analyses. New sets of instrumentation that enables modular testing capacities with integrated data bridging and progressive in silico model development systems are needed. TOXBOX will provide a device based on a prototype developed in a H2020 project, PANBioRA, with a flexible microfluidic and instrument architecture to provide a plug and play testing platform to ease accessibility and interlaboratory validation. The system will incorporate the following tests, with modifications for each step of life cycle: automated cytotoxicity and genotoxicity tests, connected barrier/metabolic tissue couples with cytokine and real-time electro-chemical read-outs, flow cycle modules with environment mimicking conditions, a testing module based on zebrafish embryo with mechanical stimuli. The system will be validated using metallic 2D structures and nanoparticles, biocides, and known endocrine disruptors. Custom made functional polypeptides (novel biocides) will be used to cover the design phase. Progressive in silico models for long term effects will be iteratively developed and used to predict each new group to be tested until good predictability is achieved with new chemical formulations (comprehensive risk assessment). A data management platform that enables interfacing with the available databases will be developed. After interlaboratory validation of the device by 4 partners, a standardization folder will be prepared, to make the device available for testing with accessibility at all stages of material life cycle assessment to different stakeholders. TOXBOX aspires to bring forth an instrument that will provide reliable toxicity data in relevant conditions for each chemical and enable reliable in silico model development.
| EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT | ? |
| Agence Nationale de la Securite Sanitaire de L Alimentation de L Environnement et du Travail | 199 875 € |
| Agencia Estatal Consejo Superior de Investigaciones Cientificas | 767 500 € |
| Aquamonitrix Ltd. | 319 375 € |
| Betthera s.r.o. | 312 500 € |
| Commissariat a L Energie Atomique et aux Energies Alternatives | 805 218 € |
| Dolmen Design and Innovation Ltd. | 397 583 € |
| Dublin City University | 751 219 € |
| Fundacion Tekniker | 300 110 € |
| KARLSRUHER INSTITUT FUER TECHNOLOGIE | 653 018 € |
| Kemijski Institut | 301 250 € |
| Preste | 384 000 € |
| Preste LLC | 0,00 € |
| Spartha Medical | 892 875 € |
| STEINBEIS 2I GmbH | 665 000 € |
| Streinbeis Advanced Risk Technologies Institute d.o.o. Kragujevac | 400 813 € |
https://cordis.europa.eu/project/id/101138387
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : EMPA Eidgenössische Materialprüfungs- und Forschungsanstalt, Dübendorf, Suisse.
