Moteur de recherche d’entreprises européennes
Financement de l’UE (1 999 265 €) : Impact du microbiote intestinal sur le métabolisme énergétique des cellules hôtes : rôle dans la santé et dans les maladies inflammatoires de l’intestin Hor27/07/2022 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Impact du microbiote intestinal sur le métabolisme énergétique des cellules hôtes : rôle dans la santé et dans les maladies inflammatoires de l’intestin
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized by inappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a role for environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion of patients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis and identification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as a strong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in the pathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunity sensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mounting the appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that the altered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims of ENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and the mechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD and design new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD. This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use of multiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it will have societal impacts due to the identification of new therapeutic strategies.
| Assistance Publique Hopitaux de Paris | 321 015 € |
| Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement | 314 250 € |
| Sorbonne Universite | 1 364 000 € |
https://cordis.europa.eu/project/id/101043802
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel.
