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UK funding (998 768 £) : Contrôle avancé des processus de fabrication d’AAV : numérisation, PAT et automatisation pour améliorer la productivité, la qualité et la cohérence Ukri01/06/2023 UK Research and Innovation, Royaume Uni
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Contrôle avancé des processus de fabrication d’AAV : numérisation, PAT et automatisation pour améliorer la productivité, la qualité et la cohérence
| Abstract | The therapeutic potential for gene therapies is transformative, where many largely intractable diseases will be treated safely, effectively and durably. Therapies are now starting to get approved (e.g. Roctavian, Zolgensma, and Luxturna), but cost remains a large barrier to entry and widespread patient access, partly due to suboptimal manufacturing processes. If gene therapies are ever going to be used to treat highly prevalent diseases, then breakthroughs need to be made in manufacturing. One area in need of improvement is process analytical technology (PAT) and continuous process monitoring. Current methods rely on laborious off-line analysis performed by highly trained operators at discrete time-points which introduces significant costs, delays and increases the chances of contamination. This project will use next-generation automation and novel PAT technologies to enable real-time characterisation and control of the manufacturing process. |
| Category | Collaborative R&D |
| Reference | 10064155 |
| Status | Closed |
| Funded period start | 01/06/2023 |
| Funded period end | 31/05/2025 |
| Funded value | £998 768,00 |
| Source | https://gtr.ukri.org/projects?ref=10064155 |
Participating Organisations
| RENTSCHLER ATMP LIMITED |
£199 388,00 |
| REFEYN LTD | |
| CELL THERAPY CATAPULT LIMITED |
£799 380,00 |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Rentschler Atmp Ltd., Londres, Royaume Uni.
