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Financement de l’UE (2 496 750 €) : REconfigurable et matière active codée par l’ADN Hor29/06/2023 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
REconfigurable et matière active codée par l’ADN
Synthetic materials exist in a broad variety of sizes, shapes and compositions leading to an impressive breadth of useful functions but tend to be case-specific. Living matter, in contrast, has the remarkable capability to sense, evolve, transform and adapt. Here, we propose to develop new DNA-encoded dynamic principles and implement them as molecular codes to program similar life-like characteristics in a variety of synthetic soft materials, ranging from evolutive DNA nanomachines to genetically encoded active interfaces. Various DNA nanostructures (DNA origamis, single-stranded tiles, DNA nanogrids) will be produced by a new concept of isothermal and reconfigurable DNA self-assembly, leading to user-defined self-assembled structures capable to adapt and morphologically transform, autonomously or in response to a stimulus. Coupling proteins to these reconfigurable nanoscaffolds will allow us to reconstitute dynamic synthetic metabolic pathways, design programmable catalytic switch or develop a new principle of nanostructure discovery by evolution. Beside encoding structural dynamics, we will also incorporate gene-containing DNA in interface-rich materials (films, drops, emulsions) to program, at a genetic level for the first time, the active behaviour and dynamic functionality of these systems. In situ cell-free expression of interfacially active proteins, such as BslA and hydrophobins, will allow us to control the interfacial properties (surface tension, visco-elasticity), either uniformly or with controlled spatio-temporal patterns. This will result in original genetically encoded active behaviours such as genetic Marangoni effects, propulsion, genophoresis or autonomous genetic sorting. Additional functionality will be brought by co-expressing useful proteins (enzymes, antibodies) at these interfaces, resulting in highly dynamic, reconfigurable, versatile and multifunctional soft materials.
| Ecole Normale Superieure | 2 496 750 € |
https://cordis.europa.eu/project/id/101096956
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Ecole Normale Superieure, Paris.