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Financement de l’UE (2 499 541 €) : Sculpture de l’activité cérébelleuse à travers des échelles de temps Hor01/12/2025 Programme de recherche et d'innovation de l'UE « Horizon »
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Texte
Sculpture de l’activité cérébelleuse à travers des échelles de temps
Long-term memories are consolidated over time, progressively becoming more stable and resistant to interference. The consolidation of motor memories is particularly robust – so much so that we use the term “like riding a bike” to describe things that we never forget. And yet, compared to declarative memory systems, relatively little is known about the neural mechanisms through which motor memories are consolidated in the brain. Several forms of motor learning require the cerebellum, a brain area that is often thought of as a machine-like input-output device in which sensory inputs are combined with state estimation to compute motor commands. However, recent work has emphasized the extent to which cerebellar circuit function is influenced by external features, such as the animal's behavioral state, or the statistics of the environment. Moreover, activity that occurs offline – between experimental sessions and even between individual trials, within sessions – can be crucial for cerebellar function. Here, we will investigate how cerebellar activity is sculpted over time, not only during the execution of cerebellum-dependent behaviors themselves, but also during offline ‘rest’ periods, and across stages of learning, to consolidate recent memories and update the system to allow it to learn new things. We will use temporally precise, cell-type-specific neural circuit manipulations and recordings to ask: 1. What are the mechanisms through which offline cerebellar activity contributes to memory consolidation? 2. What roles does memory consolidation play in long-term motor adaptation and metalearning, or ‘learning how to learn?’ 3. How do climbing fiber inputs to the cerebellum contribute to determining what is learned? Together, these experiments will reveal how cerebellar activity patterns are orchestrated across timescales to enable flexible and coordinated behavior in dynamic environments.
| The Chancellor, Masters and Scholars of the University of Oxford | 2 499 541 € |
https://cordis.europa.eu/project/id/101201249
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : THE Chancellor Masters AND Scholars OF THE University OF Oxford CHARITY, Oxford, Royaume Uni.
