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Financement de l’UE (2 689 603 €) : Un réseau de formation pour la conception de vaccins à base de glucides synthétiques dans la lutte contre l’agent pathogène nosocomial multirésistant Acinetobacter … Hor21/11/2023 Programme de recherche et d'innovation de l'UE « Horizon »
Texte
Un réseau de formation pour la conception de vaccins à base de glucides synthétiques dans la lutte contre l’agent pathogène nosocomial multirésistant Acinetobacter baumannii
Bacterial infections are a societal burden with profound medical and socio-economic impacts. Although antibiotics can be effective, the continuous emergence of bacteria with antimicrobial resistance calls for the introduction of novel therapeutics. In this regard, glycoconjugate vaccines (GV) hold a prominent role in the fight against AMR bacterial strains. They are based on the chemical conjugation of one or more pathogen-associated saccharide antigens to immunogenic carriers, leading to a long-term protective immunity. ACINETWORK will focus on the development of GV against severe and life-threatening infections caused by antimicrobial resistant Acinetobacter baumannii strains, which are a major cause of nosocomial diseases and for which no vaccine exists. ACINETWORK wants to overcome the limitations of currently licensed GV, due to highly heterogeneous composition and batch wise variability, by innovatively using structurally-defined synthetic oligosaccharide antigens to develop GV with well-defined composition, higher purity and better safety profiles. The manufacturing of such GV is also more rapid and cost-effective. Thus, this project will set synthesis and testing pipelines that will serve as the prototype for the development of GV against other bacteria. The ACINETWORK consortium comprises universities and SMEs with a unique complementary expertise, ranging from carbohydrate chemistry to nanotechnology, immunology and microbiology, which garantees the realization of the new GV. The goal of ACINETWORK is to also forge 10 young experts in the design of these novel medical solutions with an integrated training program, which will equip them with a large battery of scientific and transferable skills. The multidisciplinarity of the consortium ensures a fertile and stimulating environment in which these young researchers will acquire unique competencies in vaccine design, development and production, which will be central at putting Europe at the forefront of GV.
| Associazione Hand IN Hand | ? |
| Aarhus Universitet | 603 576 € |
| Asociacion Centro de Investigacion CRL en Biomateriales- Cic biomaGUNE | 251 971 € |
| Glycouniverse GmbH & Co. KGaA | 260 539 € |
| Institut National de la Sante et de la Recherche Medicale | 282 694 € |
| Instituto de Salud Carlos III | 251 971 € |
| MAX-Planck-Gesellschaft ZUR Forderung DER Wissenschaften e. V. | 260 539 € |
| Universita Degli Studi Di Firenze | 259 438 € |
| Universita Degli Studi Di Milano | 518 875 € |
https://cordis.europa.eu/project/id/101119795
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Associazione Hand IN Hand, Nemi, Italie.