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UK funding (625 840 £) : Perception du mouvement dans le trouble neurologique fonctionnel (TNF) Ukri01/02/2024 UK Research and Innovation, Royaume Uni
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Perception du mouvement dans le trouble neurologique fonctionnel (TNF)
| Abstract | Functional Neurological Disorder (FND) is a common, debilitating condition often causing problems with movement and balance. It is second only to headaches as a reason for referral to a neurologist, however, it is little understood and treatments are limited, leaving people with FND with few options. In this project we will study FND from a new perspective, suggesting movement symptoms might arise due to problems with the brain systems that help us to: i) Perceive movement in our environment from the motion arising on the back of the eye (the retina) ii) Control our movement through the environment. The second of these activities obviously requires the brain to estimate how we are moving, which involves combining self-movement information appropriately from a range of senses (including vision together with balance information from the inner ear). However, the first activity also relies on knowing about self-movement - the brain cannot assess how other parts of the environment are moving without taking into account our own movement first. For example, a traffic cone that is stationary in the environment will be moving on the retina if we drive past it. To establish that the cone is, in fact, 'world stationary' the brain needs to factor in and compensate for our own movement. The brain solves this this problem by rapidly predicting/estimating the motion on the retina due to self-movement and then compensating for this before interpreting the movement of other parts of the environment. Without this ability we would incorrectly interpret motion on the retina - stationary parts of the environment would seem to move and problems with balance and movement similar to those experienced in FND would follow. With these issues in mind, we will test theories suggesting that FND movement symptoms arise from inappropriate combination of sensory information about self-movement and/or estimation and compensation for our self-movement when interpreting how other parts of the world are moving. We will focus on a subgroup of FND patients with Persistent Postural-Perceptual Dizziness (3PD), who experience particularly pronounced movement symptoms and use established experimental approaches to test our hypotheses. Crucially we will also use Virtual Reality (VR) technology, which allows us to break the relationship between self-movement and the retinal movement that normally accompanies it. Using well-established methods from sensory science we will measure (for each individual) the ability to: i) estimate self-movement and movement of other parts of the environment ii) compensate for self-movement; iii) combine different sensory information sources about self-movement. We can then consider how these measures differ in those with and without 3PD and how they might predict 3PD symptoms and problems in everyday movement tasks. Having better understanding of the factors causing 3PD/FND movement symptoms, will then allow us to investigate novel VR-based therapies to reduce symptoms. For example, our pilot data suggest less compensation for self-movement in 3PD and we could counteract this by temporarily placing patients in VR environments where motion on the retina is slightly increased relative to what should normally accompany self-movement, gradually reducing this to normal over a period of time. Similarly, if we find that combination of self-movement information is altered in FND (e.g. too much emphasis placed on visual information) we could use VR to direct more attention towards the overlooked information source. Crucially, such approaches could be tailored to the individual. We anticipate that our research will lead to significantly better understanding of the causes of FND/3PD and, subsequently, better and more targeted therapies. As a consequence we are confident that this work could rapidly translate into future studies demonstrating direct benefit for a large patient group with limited treatment options. |
| Category | Research Grant |
| Reference | MR/Y004000/1 |
| Status | Active |
| Funded period start | 01/02/2024 |
| Funded period end | 31/01/2027 |
| Funded value | £625 840,00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FY004000%2F1 |
Participating Organisations
| University of Manchester | |
| Manchester University | |
| GUY'S AND ST THOMAS' NHS FOUNDATION TRUST | |
| Northern Care Alliance NHS Foundation Trust | |
| NHS LOTHIAN | |
| MANCHESTER UNIVERSITY NHS FOUNDATION TRUST |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : The University of Manchester, Manchester, Royaume Uni.
