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UK funding (573 775 £) : Développement de la plateforme Gastrobody pour lutter contre les toxines de Clostridium perfringens Ukri01/01/2023 UK Research and Innovation, Royaume Uni
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Développement de la plateforme Gastrobody pour lutter contre les toxines de Clostridium perfringens
| Abstract | Antibodies are proteins that can bind specific targets such as bacteria, viruses or toxins to stop them causing disease. Antibodies are not widely used in agriculture because, like nearly all proteins in the diet, they are quickly destroyed by the stomach and small intestine. We have generated "gastrobodies" by engineering a protein from soybeans to bind new targets. Unlike antibodies or other protein scaffolds, gastrobodies are highly resistant to the harsh digestive enzymes of the gut. Here we will test the ability of gastrobodies to protect against bacterial disease. Clostridium perfringens is a bacterium that causes a wide range of diseases affecting farmers, including in pigs, cows, sheep and chickens. These effects are caused by toxins released by the bacterium. We will establish gastrobodies that can stop these bacterial toxins in the gut from causing damage. We will focus on the toxins that cause necrotic enteritis in chickens, which has increased dramatically following the banning of antibiotics in animal feed and costs billions of pounds per year worldwide. We aim to establish the cost-effective production of gastrobodies, so that they can be simply added to animal feed and then recognise specific targets within the digestive system. These goals should set the stage for broad use of gastrobodies for gut health, with relevance to many agricultural and medical diseases. |
| Category | Research Grant |
| Reference | BB/W014297/1 |
| Status | Active |
| Funded period start | 01/01/2023 |
| Funded period end | 31/12/2025 |
| Funded value | £573 775,00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FW014297%2F1 |
Participating Organisations
| University of Cambridge | |
| AB Vista Feed Ingredients |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University of Cambridge, Cambridge, Royaume Uni.
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