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Financement de l’UE (1 749 375 €) : La possibilité d’une vie artificielle à des températures inférieures à zéro : le rôle de l’eau dans les compartiments imitant les cellules Hor23/12/2022 Programme de recherche et d'innovation de l'UE « Horizon »
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La possibilité d’une vie artificielle à des températures inférieures à zéro : le rôle de l’eau dans les compartiments imitant les cellules
In the last few decades, researchers have come to believe that where there is liquid water, there is life, regardless of the physical conditions of the surroundings. Indeed, living organisms have been discovered in environments with extreme temperatures, radiation, or high salinity. In terms of temperature, the lowest limit to sustain the metabolic activities of bacteria is reported to be -20 ºC in permafrost. Yet, the survival mechanism of life below the freezing point of water is still not fully understood, though it has important implications for origin of life studies and the search for life in the universe. The prerequisite of life at subzero temperatures is the existence of liquid water. Intracellular liquid water not only serves as solution medium, but also plays a crucial role in biological processes such as metabolisms in cells. Therefore, understanding the physical state of intracellular water at subzero temperatures is important. In ArtWater, we will employ synthetic compartments as model system to investigate the physical state of compartmentalized water at subzero temperatures. The project will be conducted through a bottom-up approach: from pure water in compartments to crowded compartmentalized solutions that mimic cytoplasm in natural cells. The crystallization, diffusion, and dynamics of water will be studied by differential scanning calorimetry, nuclear magnetic resonance, and broadband dielectric spectroscopy, respectively. Several types of state-of-the-art synthetic compartments will be employed including polymersomes, liposomes, and complex coacervates. Furthermore, we will develop artificial cells equipped with liquid water enabling biological activities at subzero temperatures. The ArtWater project will not only open the window for understanding the survival mechanisms at extremely low temperatures but also provide a new platform for tunable bioengineering processes such as cryopreservation and cryo-enzymology and shed light to astrobiology.
| Universiteit Utrecht | 1 749 375 € |
https://cordis.europa.eu/project/id/101075507
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Universiteit Utrecht, Utrecht, Pays-Bas.
